Laboratory-Scale Processor
“Laboratory in Name Only”
- The LSP-600 is a flexible laboratory ultrasonic processor designed to handle test batches with ease while providing the scale-up benchmark for larger production units. Engineered to streamline the transition from R&D to commercialization, the LSP-600 is reliable, flexible, and user-friendly.
- Download Ultrasonic Processors Comparison Chart
LSP-600 Features at a Glance:
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- Patented Barbell Horn®-based design capable of generating high amplitudes with broad amplitude control.
- Two configurations: batch and flow-through. Typical processing volumes range from 15 mL to 2 L.
- Portable, mobile, and compact, while consistently delivering powerful results.
- Equipped with state-of-the-art components and accessories, including the NRE-30 sound enclosure, flow-through storage/mixing vessel with continuous stirring, and precise temperature control.
- Capable of processing a wide range of liquids, including materials with high solids content and broad viscosity ranges.
- Delivered worldwide and mostly pre-assembled for seamless integration into your lab.
- Supported by ISM’s customer support team and detailed documentation to help users develop laboratory processes and scale them up.
- Built with cGMP compliance in mind and used worldwide to develop formulations, conduct research studies, and support clinical trials.
MAIN COMPONENTS
- Ultrasonic generator (600 W)
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Input voltage:100 Vac – 240 Vac
@ 50/60 Hz -
Rated current:10 Amps max.
- Output characteristics: 600 W (max.), 20 +/- 1 kHz (max.)
- Additional features: continuous resonance frequency lock, automatic power adjustment, fine amplitude adjustment and lock (20 – 100 %), real-time monitoring of output power and frequency, optional external control, optional pulsed operation.
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- Air-cooled piezoelectric transducer (ACT-22-LSP)
- Output characteristics: amplitude — 22 microns (max.), frequency — 20 (+/- 1) kHz, power — 600 W (max.)
- Full-wave Barbell Horn® (FBH, 21 mm tip diameter)
- Output characteristics: amplitude — 115 μm (max), frequency — 20 (+/- 1) kHz, power — 600 W (max.)
OPTIONAL ACCESSORIES
- Flow-through reactor chamber (flow cell, 1/2″ tri-clamp inlet and outlet, cooling jacket)
- Conventional horn (CH, 12.7 mm tip diameter, amplitude — 113 microns (max.))
- Support stand with clamp holders
- Noise reduction ear muffs
- Sound enclosure
- Magnetic stirrer with hotplate
- 2 L process vessel
- Peristaltic pump
- Air blower
- Water chiller
- Glass beaker
- NanoStabilizers®
- Flow-through filters
ADDITIONAL INFORMATION
- Materials of wetted parts:
- Reactor chamber — 316 stainless steel. Food compatible.
- Horns (FBH, CH, microtips) — Ti6Al4V. Food compatible.
- Gaskets — Buna-N or Teflon. Food compatible.
- O-rings — Buna-N. Food compatible.
- Noise level:
- 103 – 106 dBa at 2′ away. Noise reducing earmuffs or sound enclosure required.
- Capacity
- 15 ml – 100 ml — with CH (batch mode)
- 100 ml – 500 ml — with FBH (batch mode)
- 500 ml – 2 L — with FBH + reactor chamber (flow-through mode).
- Productivity rates
- Productivity rates are highly dependent on the nature of each process and range from about 200 mL/h for challenging tasks (e.g., top-down nanocrystallization of active pharmaceutical compounds) to over 10 L/h for fast processes (e.g., degassing, deagglomeration).
LSP-600: Unbox and Assembly Procedure
Batch-Mode.
LSP-600: Unbox & Assembly Procedures.
Flow-Through Mode.
Water in Oil Nanoemulsion Prepared by High-Intensity Ultrasound.
Batch Mode.
Ultrasonic Degassing Test with LSP-600 Processor.
Batch Mode.
Frequently Asked Questions
What is the LSP-600 ultrasonic processor used for?
The LSP-600 is ISM’s laboratory-scale ultrasonic processor designed for feasibility testing, R&D, and process optimization. It is used for nanoemulsion formulation, extraction and cell disruption, degassing, dispersing and deagglomeration, and nano-crystallization at lab scale. It handles liquid volumes from 15 mL to 2 L and operates in both batch and flow-through configurations.
What makes the LSP-600 different from a standard lab sonicator?
Unlike conventional lab sonicators, the LSP-600 uses ISM’s patented Barbell Horn® Ultrasonic Technology (BHUT), which generates significantly higher ultrasonic amplitudes (up to 100 microns) than standard probes. It is also engineered for direct scale-up — any process developed on the LSP-600 can be transferred to the BSP-1200 or ISP-3600 without re-optimization.
What is the processing capacity of the LSP-600?
The LSP-600 handles 15 mL to 100 mL in batch mode with the Conventional Horn (CH), 100 mL to 500 mL in batch mode with the Full-Wave Barbell Horn (FBH), and 500 mL to 2 L in flow-through mode. Productivity rates range from approximately 200 mL/h for demanding tasks like pharmaceutical nanocrystallization, up to 10+ L/h for fast processes like degassing.
Is the LSP-600 globally compliant?
The LSP-600 is built with global compliance in mind. All wetted parts — 316 stainless steel reactor chamber, Ti6Al4V titanium horns, and Buna-N or Teflon gaskets — are food compatible. It carries CE and TÜV certification and is used globally in pharmaceutical research studies and various R&D trials.
Can the LSP-600 scale up to production?
Yes. The LSP-600 is specifically designed as the first step in ISM’s scale-up pathway: LSP-600 (lab) → BSP-1200 (bench) → ISP-3600 (industrial). Because all three processors use the same BHUT technology, process parameters developed on the LSP-600 transfer directly — with no loss in amplitude, processing conditions, or result reproducibility.
