- Make water-soluble CBD and THC nanoemulsions with enhanced bioavailability and rapid onset of action.
- Ensure precise and reproducible therapeutic dosing.
- Infuse water with a strong dose of cannabinoids while retaining optical clarity.
- Extract cannabis oil using water as a solvent.
Overview
Our patented Barbell Horn® Ultrasonic Technology (BHUT) and over a decade of experience in the pharmaceutical industry enables us to offer a very effective solution: cannabis extract nanoemulsions. These formulations are fully water-compatible, kinetically stable, provide exceptional therapeutic effects, and are absorbed by the body very rapidly and completely, exhibiting higher potency and faster onset of action for lower doses. Since nanoemulsions can be made translucent, they are easily mixed into water (or any other beverage) without compromising its optical clarity. In addition, since our technology makes oils water-compatible (aka. water-soluble), it can be used to extract cannabis oil from plants directly into water, avoiding dangerous organic solvents. With Industrial Sonomechanics® laboratory, bench, and industrial ultrasonic systems, these processes can be implemented at any scale of operation, guaranteeing reproducible and predictable results.
Case Studies & Application Reports
Blog Posts
Recap: 4th International Process Intensification Conference (IPIC4)
Industrial Sonomechanics (ISM) was honored to participate in the 4th International Pro...
Read more...
Recap: Adhesives & Bonding Expo
Industrial Sonomechanics (ISM) had a great time exhibiting at the Adhesives and Bondin...
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Pro-Lite™: Semi-Automated Ultrasonic Extractor for Pilot-Scale Production
We are excited to spotlight theUltrasonic Extractor Pro-Lite™— a semi-automated ultrason...
Read more...Customer Testimonials
Khara Cartagena, Cannabis and Hemp Productions
Videos
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ISM’s Barbell Horn Ultrasonic Technology Introduction and How We Scale Up
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Can CBD or THC be Made Water-Soluble with ISM’s Ultrasonic Technology?
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Making a Translucent Nanoemulsion with ISP-3000 in the Flow-Through Mode
Ebooks
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MAKING STABLE EMULSIONS: A Guide to Formulation and Processing Conditions Optimization
FAQs
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CANNABIS PROCESSING: Frequently Asked Questions
Frequently Asked Questions
What is the LSP-600 ultrasonic processor used for?
The LSP-600 is ISM’s laboratory-scale ultrasonic processor designed for feasibility testing, R&D, and process optimization. It is used for nanoemulsion formulation, extraction and cell disruption, degassing, dispersing and deagglomeration, and nano-crystallization at lab scale. It handles liquid volumes from 15 mL to 2 L and operates in both batch and flow-through configurations.
What makes the LSP-600 different from a standard lab sonicator?
Unlike conventional lab sonicators, the LSP-600 uses ISM’s patented Barbell Horn® Ultrasonic Technology (BHUT), which generates significantly higher ultrasonic amplitudes (up to 100 microns) than standard probes. It is also engineered for direct scale-up — any process developed on the LSP-600 can be transferred to the BSP-1200 or ISP-3600 without re-optimization.
What is the processing capacity of the LSP-600?
The LSP-600 handles 15 mL to 100 mL in batch mode with the Conventional Horn (CH), 100 mL to 500 mL in batch mode with the Full-Wave Barbell Horn (FBH), and 500 mL to 2 L in flow-through mode. Productivity rates range from approximately 200 mL/h for demanding tasks like pharmaceutical nanocrystallization, up to 10+ L/h for fast processes like degassing.
Is the LSP-600 globally compliant?
The LSP-600 is built with global compliance in mind. All wetted parts — 316 stainless steel reactor chamber, Ti6Al4V titanium horns, and Buna-N or Teflon gaskets — are food compatible. It carries CE and TÜV certification and is used globally in pharmaceutical research studies and various R&D trials.
Can the LSP-600 scale up to production?
Yes. The LSP-600 is specifically designed as the first step in ISM’s scale-up pathway: LSP-600 (lab) → BSP-1200 (bench) → ISP-3600 (industrial). Because all three processors use the same BHUT technology, process parameters developed on the LSP-600 transfer directly — with no loss in amplitude, processing conditions, or result reproducibility.
