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Home > Extraction & Cell Disruption

Extraction & Cell Disruption

cell disruption-1
High-intensity ultrasound is extremely effective at extracting substances from plants, mushrooms and microorganisms. Rapid, high-yield extraction of alkaloids, cannabinoids, terpenes, polyphenols, recombinant proteins, and many other bioactives is possible, in many cases even when harsh organic solvents are replaced with green alternatives, such as ethanol or water.

Overview

Ultrasonic cell disruption (lysing) is the “gold standard” extraction method, owing to its simplicity and superior efficiency in extracting a wide variety of substances from plants, mushrooms and microorganisms, including cannabinoids, alkaloids, terpenes, algae oils, polyphenols, and recombinant proteins. This process is conducted using an ultrasonic processor equipped with a high-amplitude Barbell Horn® immersed in a biomass slurry prepared with a suitable solvent. High vibration amplitudes are required as this process relies on intense acoustic cavitation to generate extremely strong solvent micro-jets able to disrupt/penetrate cell membranes and bring out their contents.

The main advantage of Industrial Sonomechanics® ultrasonic processors for this application is the ability of our patented Barbell Horns® to generate very high ultrasonic amplitudes at any scale of operation (unlike conventional high-amplitude ultrasonic horns, which are restricted to the laboratory scale only). Since our processors can be configured in both batch and flow-through modes, they can handle anywhere from a few milliliters to many hundreds of liters of slurry at a time. Our reactor chambers (flow cells) are designed without narrow gaps or capillaries, eliminating clogging that is common with some alternative approaches. For biomass slurries with a strong tendency to settle out of the solvent, we offer a flow-through processor configuration with an incorporated in-line high-shear mixing pump.

All Industrial Sonomechanics® units provide precise temperature control, making it possible to extract heat-sensitive substances. Our bench and industrial-scale processors utilize patented fully sealed water-cooled transducers and can, therefore, work with flammable organic solvents. However, since high-amplitude ultrasound is able to greatly intensify the efficiency of extraction, it is often possible to replace harsh organic solvents with milder, greener and more economical food-grade alternatives, such as ethanol or water, and still achieve superior results.
cell disruption extraction-2

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Case Studies & Application Reports

Ultrasonic Disruption of Yeast Cells
CASE STUDY
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Microalgal Oil Extraction and Transesterification
APPLICATION REPORT
Download PDF
Cell Disruption for Recombinant Protein Production
APPLICATION REPORT
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View All case studies

Blog Posts

Vaccine and Antiviral Drug Production with ISM Ultrasonic Processors
04/28/20

Vaccine and Antiviral Drug Production with ISM Ultrasonic Processors

Recent years have seen major breakthroughs in how vaccines and antiv... Read more...
Cannabis Concentrates: Medical Significance and Extraction Methods
10/22/16

Cannabis Concentrates: Medical Significance and Extraction Methods

The cannabis (marijuana, hemp) plant has been used for medicinal pur... Read more...
Acoustic Cavitation: The Driving Force Behind Ultrasonic Processing
01/02/16

Acoustic Cavitation: The Driving Force Behind Ultrasonic Processing

Liquids exposed to high-intensity ultrasound can undergo acoustic ca... Read more...
Read All Blog Posts

Customer Testimonials

Dominic Notter, Matrix of Life

“ISM supplied us with their industrial-scale ultrasonic processor, ISP-3000, which we have been using to make nutraceutical and cosmetic products, as well as for essential oil extraction and several similar applications for over a year. We are pleased to say that with this processor, the efficiency of plant oil extraction, emulsification and solids’ dispersion is superb, enabling us to make products comprising dozens of different oils, solid powders and water. The products seem to remain permanently stable and have many other enhanced properties: our customers consistently report superior taste, texture and overall performance. We look forward to using this technology for developing many new processes in the near future.”
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Videos

  • Algae Oil Extraction Using High-Intensity Ultrasound
  • ISM’s Barbell Horn® Ultrasonic Technology Introduction and How We Scale Up
  • Ultrasonic Cavitation Produced by HBHO at Amplitudes of 30 and 100 microns
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Ebooks

  • MAKING STABLE EMULSIONS A Guide to Formulation and Processing Conditions Optimization
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FAQs

  • Ultrasonic Cell Disruption (Lysis) and Extraction FAQ’S
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7440 SW 50th Terrace #110
Miami, FL 33155
Address: 7440 SW 50th Terrace #110 Miami, FL 33155
Email: contact@sonomechanics.com
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